Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G(2) phase by mismatch repair

Here we examined the role of cellular vitamin C in genotoxicity of carcinogenic chromium(VI) that requires reduction to induce DNA damage. In the presence of ascorbate (Asc), low 0.2–2 μM doses of Cr(VI) caused 10–15 times more chromosomal breakage in primary human bronchial epithelial cells or lung...

Descripción completa

Detalles Bibliográficos
Autores principales: Reynolds, Mindy, Stoddard, Lauren, Bespalov, Ivan, Zhitkovich, Anatoly
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802609/
https://www.ncbi.nlm.nih.gov/pubmed/17169990
http://dx.doi.org/10.1093/nar/gkl1069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802609/
https://www.ncbi.nlm.nih.gov/pubmed/17169990
http://dx.doi.org/10.1093/nar/gkl1069

Ejemplares similares