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Selenium derivatization of nucleic acids for crystallography

The high-resolution structure of the DNA (5′-GTGTACA-C-3′) with the selenium derivatization at the 2′-position of T2 was determined via MAD and SAD phasing. The selenium-derivatized structure (1.28 Å resolution) with the 2′-Se modification in the minor groove is isomorphorous to the native structure...

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Detalles Bibliográficos
Autores principales: Jiang, Jiansheng, Sheng, Jia, Carrasco, Nicolas, Huang, Zhen
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802610/
https://www.ncbi.nlm.nih.gov/pubmed/17169989
http://dx.doi.org/10.1093/nar/gkl1070