Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

A series of antisense oligonucleotides (ASOs) containing either 2′-O-methoxyethylribose (MOE) or locked nucleic acid (LNA) modifications were designed to investigate whether LNA antisense oligonucleotides (ASOs) have the potential to improve upon MOE based ASO therapeutics. Some, but not all, LNA co...

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Detalles Bibliográficos
Autores principales: Swayze, Eric E., Siwkowski, Andrew M., Wancewicz, Edward V., Migawa, Michael T., Wyrzykiewicz, Tadeusz K., Hung, Gene, Monia, Brett P., Bennett, and C. Frank
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802611/
https://www.ncbi.nlm.nih.gov/pubmed/17182632
http://dx.doi.org/10.1093/nar/gkl1071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802611/
https://www.ncbi.nlm.nih.gov/pubmed/17182632
http://dx.doi.org/10.1093/nar/gkl1071

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