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Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
BACKGROUND: The rapid desensitization of the human prostacyclin (IP) in response to agonist binding has been shown in cell culture. Phosphorylation of the IP receptor by protein kinase C (PKC) has been suggested to be involved in this process. METHODS AND RESULTS: In this study we investigated the v...
Autores principales: | Schermuly, Ralph T, Pullamsetti, Soni S, Breitenbach, Susanne C, Weissmann, Norbert, Ghofrani, Hossein A, Grimminger, Friedrich, Nilius, Sigrid M, Schrör, Karsten, Meger-Kirchrath, Jutta, Seeger, Werner, Rose, Frank |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802745/ https://www.ncbi.nlm.nih.gov/pubmed/17257398 http://dx.doi.org/10.1186/1465-9921-8-4 |
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