The Role of Mitochondrial DNA Mutations in Mammalian Aging

Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mit...

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Detalles Bibliográficos
Autores principales: Kujoth, Gregory C, Bradshaw, Patrick C, Haroon, Suraiya, Prolla, Tomas A
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802824/
https://www.ncbi.nlm.nih.gov/pubmed/17319745
http://dx.doi.org/10.1371/journal.pgen.0030024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802824/
https://www.ncbi.nlm.nih.gov/pubmed/17319745
http://dx.doi.org/10.1371/journal.pgen.0030024

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