The Role of Mitochondrial DNA Mutations in Mammalian Aging

Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mit...

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Detalles Bibliográficos
Autores principales: Kujoth, Gregory C, Bradshaw, Patrick C, Haroon, Suraiya, Prolla, Tomas A
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802824/
https://www.ncbi.nlm.nih.gov/pubmed/17319745
http://dx.doi.org/10.1371/journal.pgen.0030024
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author Kujoth, Gregory C
Bradshaw, Patrick C
Haroon, Suraiya
Prolla, Tomas A
author_facet Kujoth, Gregory C
Bradshaw, Patrick C
Haroon, Suraiya
Prolla, Tomas A
author_sort Kujoth, Gregory C
collection PubMed
description Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mitochondrial genome instability. We also discuss potential mechanisms for the generation of these mutations and the means by which they may mediate their pathological consequences. Strategies for slowing the accumulation and attenuating the effects of mtDNA mutations are discussed.
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spelling pubmed-18028242007-02-22 The Role of Mitochondrial DNA Mutations in Mammalian Aging Kujoth, Gregory C Bradshaw, Patrick C Haroon, Suraiya Prolla, Tomas A PLoS Genet Review Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mitochondrial genome instability. We also discuss potential mechanisms for the generation of these mutations and the means by which they may mediate their pathological consequences. Strategies for slowing the accumulation and attenuating the effects of mtDNA mutations are discussed. Public Library of Science 2007-02 2007-02-23 /pmc/articles/PMC1802824/ /pubmed/17319745 http://dx.doi.org/10.1371/journal.pgen.0030024 Text en © 2007 Kujoth et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Kujoth, Gregory C
Bradshaw, Patrick C
Haroon, Suraiya
Prolla, Tomas A
The Role of Mitochondrial DNA Mutations in Mammalian Aging
title The Role of Mitochondrial DNA Mutations in Mammalian Aging
title_full The Role of Mitochondrial DNA Mutations in Mammalian Aging
title_fullStr The Role of Mitochondrial DNA Mutations in Mammalian Aging
title_full_unstemmed The Role of Mitochondrial DNA Mutations in Mammalian Aging
title_short The Role of Mitochondrial DNA Mutations in Mammalian Aging
title_sort role of mitochondrial dna mutations in mammalian aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802824/
https://www.ncbi.nlm.nih.gov/pubmed/17319745
http://dx.doi.org/10.1371/journal.pgen.0030024
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