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Considerations in the identification of functional RNA structural elements in genomic alignments

BACKGROUND: Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and score potential RNA secondary structures on the basis of thermodynamic stability, conservation, and/or covariance in seque...

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Detalles Bibliográficos
Autores principales: Babak, Tomas, Blencowe, Benjamin J, Hughes, Timothy R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803800/
https://www.ncbi.nlm.nih.gov/pubmed/17263882
http://dx.doi.org/10.1186/1471-2105-8-33