Cargando…

Meta-Analysis in Genome-Wide Association Datasets: Strategies and Application in Parkinson Disease

BACKGROUND: Genome-wide association studies hold substantial promise for identifying common genetic variants that regulate susceptibility to complex diseases. However, for the detection of small genetic effects, single studies may be underpowered. Power may be improved by combining genome-wide datas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Evangelou, Evangelos, Maraganore, Demetrius M., Ioannidis, John P.A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805816/ https://www.ncbi.nlm.nih.gov/pubmed/17332845 http://dx.doi.org/10.1371/journal.pone.0000196

Ejemplares similares

Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations
por: Ioannidis, John P.A., et al.
Publicado: (2007)

Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease
por: Maraganore, Demetrius M.
Publicado: (2011)

Can Lessons Learned from Genome-Wide Research be Applied to Nutrition-Wide and Exposure-Wide Evidence?
por: Ioannidis, John P.A.
Publicado: (2010)

A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease
por: Lesnick, Timothy G, et al.
Publicado: (2007)

Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway
por: Lesnick, Timothy G., et al.
Publicado: (2008)

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
por: Nalls, Mike A, et al.
Publicado: (2014)

Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes
por: Alfradique-Dunham, Isabel, et al.
Publicado: (2021)

Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort
por: Markopoulou, Katerina, et al.
Publicado: (2021)

Reproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies
por: O’Sullivan, Jack W., et al.
Publicado: (2021)

Genome-wide Analysis of Motor Progression in Parkinson Disease
por: Martínez Carrasco, Alejandro, et al.
Publicado: (2023)

The Parkinson's Disease Genome‐Wide Association Study Locus Browser
por: Grenn, Francis P., et al.
Publicado: (2020)

Systematic identification of correlates of HIV infection: an X-wide association study
por: Patel, Chirag J., et al.
Publicado: (2018)

Reporting of Human Genome Epidemiology (HuGE) association studies: An empirical assessment
por: Yesupriya, Ajay, et al.
Publicado: (2008)

International ranking systems for universities and institutions: a critical appraisal
por: Ioannidis, John PA, et al.
Publicado: (2007)

An application of Random Forests to a genome-wide association dataset: Methodological considerations & new findings
por: Goldstein, Benjamin A, et al.
Publicado: (2010)

Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort – extension of the LONG-PD study
por: Chase, Bruce A., et al.
Publicado: (2023)

Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson’s Disease
por: Tan, Manuela M.X., et al.
Publicado: (2021)

Network meta-analyses performed by contracting companies and commissioned by industry
por: Schuit, Ewoud, et al.
Publicado: (2016)

Application of the anatomical fiducials framework to a clinical dataset of patients with Parkinson’s disease
por: Abbass, Mohamad, et al.
Publicado: (2021)

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses
por: Bellou, Vanesa, et al.
Publicado: (2018)

Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium
por: Grover, Sandeep, et al.
Publicado: (2022)

Prepandemic cross-reactive humoral immunity to SARS-CoV-2 in Africa: Systematic review and meta-analysis
por: Ioannidis, John P.A., et al.
Publicado: (2023)

Ethnicity- and sex-specific genome wide association study on Parkinson’s disease
por: Park, Kye Won, et al.
Publicado: (2023)

Genome-wide linkage and association mapping of disease genes with the GAW14 simulated datasets
por: Carter, Kim W, et al.
Publicado: (2005)

Genome Wide Assessment of Young Onset Parkinson’s Disease from Finland
por: Hernandez, Dena G., et al.
Publicado: (2012)

Fifty-Year Fate and Impact of General Medical Journals
por: Ioannidis, John P. A., et al.
Publicado: (2010)

Laboratory Mouse Models for the Human Genome-Wide Associations
por: Kitsios, Georgios D., et al.
Publicado: (2010)

The use of older studies in meta-analyses of medical interventions: a survey
por: Patsopoulos, Nikolaos A, et al.
Publicado: (2009)

Longitudinal Monitoring of Parkinson's Disease in Different Ethnic Cohorts: The DodoNA and LONG-PD Study
por: Markopoulou, Katerina, et al.
Publicado: (2020)

Genome-Wide Datasets of Chicories (Cichorium intybus L.) for Marker-Assisted Crop Breeding Applications: A Systematic Review and Meta-Analysis
por: Draga, Samela, et al.
Publicado: (2023)

Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease
por: Simon-Sanchez, Javier, et al.
Publicado: (2009)

Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila
por: Fernandes, Caroline, et al.
Publicado: (2011)

Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics
por: McGill, Sarah K, et al.
Publicado: (2013)

Family-Based versus Unrelated Case-Control Designs for Genetic Associations
por: Evangelou, Evangelos, et al.
Publicado: (2006)

Are randomized trials obsolete or more important than ever in the genomic era?
por: Ioannidis, John PA, et al.
Publicado: (2013)

Processing genome-wide association studies within a repository of heterogeneous genomic datasets
por: Bernasconi, Anna, et al.
Publicado: (2023)

Validity of observational evidence on putative risk and protective factors: appraisal of 3744 meta-analyses on 57 topics
por: Janiaud, Perrine, et al.
Publicado: (2021)

Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease
por: Rosenberger, Albert, et al.
Publicado: (2007)

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets
por: Rahmioglu, Nilufer, et al.
Publicado: (2014)

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database
por: Lill, Christina M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_g9jhbqumnohvfn7d2b48ngg20v