Increased Expression of the Auxiliary β(2)-subunit of Ventricular L-type Ca(2+) Channels Leads to Single-Channel Activity Characteristic of Heart Failure

BACKGROUND: Increased activity of single ventricular L-type Ca(2+)-channels (L-VDCC) is a hallmark in human heart failure. Recent findings suggest differential modulation by several auxiliary β-subunits as a possible explanation. METHODS AND RESULTS: By molecular and functional analyses of human and...

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Detalles Bibliográficos
Autores principales: Hullin, Roger, Matthes, Jan, von Vietinghoff, Sibylle, Bodi, Ilona, Rubio, Marta, D'Souza, Karen, Friedrich Khan, Ismail, Rottländer, Dennis, Hoppe, Uta C., Mohacsi, Paul, Schmitteckert, Eva, Gilsbach, Ralf, Bünemann, Moritz, Hein, Lutz, Schwartz, Arnold, Herzig, Stefan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808423/
https://www.ncbi.nlm.nih.gov/pubmed/17356701
http://dx.doi.org/10.1371/journal.pone.0000292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808423/
https://www.ncbi.nlm.nih.gov/pubmed/17356701
http://dx.doi.org/10.1371/journal.pone.0000292

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