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Increased Expression of the Auxiliary β(2)-subunit of Ventricular L-type Ca(2+) Channels Leads to Single-Channel Activity Characteristic of Heart Failure
BACKGROUND: Increased activity of single ventricular L-type Ca(2+)-channels (L-VDCC) is a hallmark in human heart failure. Recent findings suggest differential modulation by several auxiliary β-subunits as a possible explanation. METHODS AND RESULTS: By molecular and functional analyses of human and...
Autores principales: | Hullin, Roger, Matthes, Jan, von Vietinghoff, Sibylle, Bodi, Ilona, Rubio, Marta, D'Souza, Karen, Friedrich Khan, Ismail, Rottländer, Dennis, Hoppe, Uta C., Mohacsi, Paul, Schmitteckert, Eva, Gilsbach, Ralf, Bünemann, Moritz, Hein, Lutz, Schwartz, Arnold, Herzig, Stefan |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808423/ https://www.ncbi.nlm.nih.gov/pubmed/17356701 http://dx.doi.org/10.1371/journal.pone.0000292 |
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