Deregulated Replication Licensing Causes DNA Fragmentation Consistent with Head-to-Tail Fork Collision

Correct regulation of the replication licensing system ensures that no DNA is rereplicated in a single cell cycle. When the licensing protein Cdt1 is overexpressed in G2 phase of the cell cycle, replication origins are relicensed and the DNA is rereplicated. At the same time, checkpoint pathways are...

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Detalles Bibliográficos
Autores principales: Davidson, Iain F., Li, Anatoliy, Blow, J. Julian
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819398/
https://www.ncbi.nlm.nih.gov/pubmed/17081992
http://dx.doi.org/10.1016/j.molcel.2006.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819398/
https://www.ncbi.nlm.nih.gov/pubmed/17081992
http://dx.doi.org/10.1016/j.molcel.2006.09.010

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