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Deregulated Replication Licensing Causes DNA Fragmentation Consistent with Head-to-Tail Fork Collision
Correct regulation of the replication licensing system ensures that no DNA is rereplicated in a single cell cycle. When the licensing protein Cdt1 is overexpressed in G2 phase of the cell cycle, replication origins are relicensed and the DNA is rereplicated. At the same time, checkpoint pathways are...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819398/ https://www.ncbi.nlm.nih.gov/pubmed/17081992 http://dx.doi.org/10.1016/j.molcel.2006.09.010 |