LPS Responsiveness and Neutrophil Chemotaxis In Vivo Require PMN MMP-8 Activity

We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)∼Val...

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Detalles Bibliográficos
Autores principales: Tester, Angus M., Cox, Jennifer H., Connor, Andrea R., Starr, Amanda E., Dean, Richard A., Puente, Xose S., López-Otín, Carlos, Overall, Christopher M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819564/
https://www.ncbi.nlm.nih.gov/pubmed/17375198
http://dx.doi.org/10.1371/journal.pone.0000312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819564/
https://www.ncbi.nlm.nih.gov/pubmed/17375198
http://dx.doi.org/10.1371/journal.pone.0000312

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