Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation

The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound to ANTXR1, but only at pH ∼5.0 or below when it is bound to ANTXR2. Here, stru...

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Detalles Bibliográficos
Autores principales: Scobie, Heather M., Marlett, John M., Rainey, G. Jonah A., Lacy, D. Borden, Collier, R. John, Young, John A.T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824706/
https://www.ncbi.nlm.nih.gov/pubmed/17389920
http://dx.doi.org/10.1371/journal.pone.0000329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824706/
https://www.ncbi.nlm.nih.gov/pubmed/17389920
http://dx.doi.org/10.1371/journal.pone.0000329

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