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Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation
The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound to ANTXR1, but only at pH ∼5.0 or below when it is bound to ANTXR2. Here, stru...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824706/ https://www.ncbi.nlm.nih.gov/pubmed/17389920 http://dx.doi.org/10.1371/journal.pone.0000329 |