Mechanisms of Copper Ion Mediated Huntington's Disease Progression

Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of HD patients, but the role of these metals in...

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Detalles Bibliográficos
Autores principales: Fox, Jonathan H., Kama, Jibrin A., Lieberman, Gregory, Chopra, Raman, Dorsey, Kate, Chopra, Vanita, Volitakis, Irene, Cherny, Robert A., Bush, Ashley I., Hersch, Steven
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828629/
https://www.ncbi.nlm.nih.gov/pubmed/17396163
http://dx.doi.org/10.1371/journal.pone.0000334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828629/
https://www.ncbi.nlm.nih.gov/pubmed/17396163
http://dx.doi.org/10.1371/journal.pone.0000334

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