Mad3 KEN Boxes Mediate both Cdc20 and Mad3 Turnover, and Are Critical for the Spindle Checkpoint

Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins for degradation. In the presence of defective...

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Detalles Bibliográficos
Autores principales: King, Emma M.J., van der Sar, Sjaak J.A., Hardwick, Kevin G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829190/
https://www.ncbi.nlm.nih.gov/pubmed/17406666
http://dx.doi.org/10.1371/journal.pone.0000342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829190/
https://www.ncbi.nlm.nih.gov/pubmed/17406666
http://dx.doi.org/10.1371/journal.pone.0000342

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