Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity

We have studied the effects associated with two single amino acid substitution mutations in HIV-1 capsid (CA), the E98A and E187G. Both amino acids are well conserved among all major HIV-1 subtypes. HIV-1 infectivity is critically dependent on proper CA cone formation and mutations in CA are lethal...

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Detalles Bibliográficos
Autores principales: Abdurahman, Samir, Höglund, Stefan, Höglund, Anders, Vahlne, Anders
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832212/
https://www.ncbi.nlm.nih.gov/pubmed/17371591
http://dx.doi.org/10.1186/1742-4690-4-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832212/
https://www.ncbi.nlm.nih.gov/pubmed/17371591
http://dx.doi.org/10.1186/1742-4690-4-19

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