The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms

BACKGROUND: Inhibition of intestinal peristalsis is a major side effect of opioid analgesics. Although tramadol is an opioid-like analgesic, its effect on gut motility is little known. Therefore, the effect of (+)-tramadol, (-)-tramadol and the major metabolite O-desmethyltramadol on intestinal peri...

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Detalles Bibliográficos
Autores principales: Herbert, Michael K, Weis, Rebecca, Holzer, Peter
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839083/
https://www.ncbi.nlm.nih.gov/pubmed/17367519
http://dx.doi.org/10.1186/1471-2210-7-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839083/
https://www.ncbi.nlm.nih.gov/pubmed/17367519
http://dx.doi.org/10.1186/1471-2210-7-5

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