Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related...

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Autores principales: Gillet, Nicolas, Florins, Arnaud, Boxus, Mathieu, Burteau, Catherine, Nigro, Annamaria, Vandermeers, Fabian, Balon, Hervé, Bouzar, Amel-Baya, Defoiche, Julien, Burny, Arsène, Reichert, Michal, Kettmann, Richard, Willems, Luc
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839114/
https://www.ncbi.nlm.nih.gov/pubmed/17362524
http://dx.doi.org/10.1186/1742-4690-4-18
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author Gillet, Nicolas
Florins, Arnaud
Boxus, Mathieu
Burteau, Catherine
Nigro, Annamaria
Vandermeers, Fabian
Balon, Hervé
Bouzar, Amel-Baya
Defoiche, Julien
Burny, Arsène
Reichert, Michal
Kettmann, Richard
Willems, Luc
author_facet Gillet, Nicolas
Florins, Arnaud
Boxus, Mathieu
Burteau, Catherine
Nigro, Annamaria
Vandermeers, Fabian
Balon, Hervé
Bouzar, Amel-Baya
Defoiche, Julien
Burny, Arsène
Reichert, Michal
Kettmann, Richard
Willems, Luc
author_sort Gillet, Nicolas
collection PubMed
description In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
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spelling pubmed-18391142007-03-30 Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human Gillet, Nicolas Florins, Arnaud Boxus, Mathieu Burteau, Catherine Nigro, Annamaria Vandermeers, Fabian Balon, Hervé Bouzar, Amel-Baya Defoiche, Julien Burny, Arsène Reichert, Michal Kettmann, Richard Willems, Luc Retrovirology Review In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far. BioMed Central 2007-03-16 /pmc/articles/PMC1839114/ /pubmed/17362524 http://dx.doi.org/10.1186/1742-4690-4-18 Text en Copyright © 2007 Gillet et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gillet, Nicolas
Florins, Arnaud
Boxus, Mathieu
Burteau, Catherine
Nigro, Annamaria
Vandermeers, Fabian
Balon, Hervé
Bouzar, Amel-Baya
Defoiche, Julien
Burny, Arsène
Reichert, Michal
Kettmann, Richard
Willems, Luc
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
title Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
title_full Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
title_fullStr Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
title_full_unstemmed Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
title_short Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
title_sort mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839114/
https://www.ncbi.nlm.nih.gov/pubmed/17362524
http://dx.doi.org/10.1186/1742-4690-4-18
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