Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β

BACKGROUND: XIAP-associated factor 1 (XAF1) is a putative tumor suppressor that exerts its proapoptotic effects through both caspase-dependent and – independent means. Loss of XAF1 expression through promoter methylation has been implicated in the process of tumorigenesis in a variety of cancers. In...

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Detalles Bibliográficos
Autores principales: Micali, O Cristina, Cheung, Herman H, Plenchette, Stéphanie, Hurley, Sandra L, Liston, Peter, LaCasse, Eric C, Korneluk, Robert G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1845166/
https://www.ncbi.nlm.nih.gov/pubmed/17376236
http://dx.doi.org/10.1186/1471-2407-7-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1845166/
https://www.ncbi.nlm.nih.gov/pubmed/17376236
http://dx.doi.org/10.1186/1471-2407-7-52

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