Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft

BACKGROUND: The N-terminal SH2 domain (N-SH2) of the non-receptor tyrosine phosphatase SHP-2 is involved both in localization of SHP-2 by recognition of phosphotyrosine (pY) peptides and self-inhibition of SHP-2 phosphatase activity through the formation of a protein – protein interface with the pho...

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Detalles Bibliográficos
Autores principales: Guvench, Olgun, Qu, Cheng-Kui, MacKerell, Alexander D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847519/
https://www.ncbi.nlm.nih.gov/pubmed/17378938
http://dx.doi.org/10.1186/1472-6807-7-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847519/
https://www.ncbi.nlm.nih.gov/pubmed/17378938
http://dx.doi.org/10.1186/1472-6807-7-14

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