Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli

Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap the gyrase molecule at the DNA cleavage stage. Owing to this interaction, double-stranded DNA...

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Detalles Bibliográficos
Autores principales: Dwyer, Daniel J, Kohanski, Michael A, Hayete, Boris, Collins, James J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847949/
https://www.ncbi.nlm.nih.gov/pubmed/17353933
http://dx.doi.org/10.1038/msb4100135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847949/
https://www.ncbi.nlm.nih.gov/pubmed/17353933
http://dx.doi.org/10.1038/msb4100135

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