Extracellular Sulfatases, Elements of the Wnt Signaling Pathway, Positively Regulate Growth and Tumorigenicity of Human Pancreatic Cancer Cells

BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are control elements in Wnt signaling, which bind extracellularly to Wnt ligands and regulate their ability to interact with signal transduction receptors on the cell surface. Sulf-1 and Sulf-2 are novel extracellular sulfatases that act on internal...

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Detalles Bibliográficos
Autores principales: Nawroth, Roman, van Zante, Annemieke, Cervantes, Sara, McManus, Michael, Hebrok, Matthias, Rosen, Steven D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849966/
https://www.ncbi.nlm.nih.gov/pubmed/17460759
http://dx.doi.org/10.1371/journal.pone.0000392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849966/
https://www.ncbi.nlm.nih.gov/pubmed/17460759
http://dx.doi.org/10.1371/journal.pone.0000392

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