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Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications

For the exceptional self-renewal capacity, regulated cell proliferation and differential potential to a wide variety of cell types, the stem cells must maintain the intact genome. The cells under continuous exogenous and endogenous genotoxic stress accumulate DNA errors, drive proliferative expansio...

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Detalles Bibliográficos
Autor principal: Vaish, Minal
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851711/
https://www.ncbi.nlm.nih.gov/pubmed/17407576
http://dx.doi.org/10.1186/1476-4598-6-26