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Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications
For the exceptional self-renewal capacity, regulated cell proliferation and differential potential to a wide variety of cell types, the stem cells must maintain the intact genome. The cells under continuous exogenous and endogenous genotoxic stress accumulate DNA errors, drive proliferative expansio...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851711/ https://www.ncbi.nlm.nih.gov/pubmed/17407576 http://dx.doi.org/10.1186/1476-4598-6-26 |