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Ubp43 gene expression is required for normal Isg15 expression and fetal development

BACKGROUND: Isg15 covalently modifies murine endometrial proteins in response to early pregnancy. Isg15 can also be severed from targeted proteins by a specific protease called Ubp43 (Usp18). Mice lacking Ubp43 (null) form increased conjugated Isg15 in response to interferon. The Isg15 system has no...

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Detalles Bibliográficos
Autores principales: Rempel, Lea A, Austin, Kathleen J, Ritchie, Kenneth J, Yan, Ming, Shen, Meifeng, Zhang, Dong-Er, Henkes, Luiz E, Hansen, Thomas R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852108/
https://www.ncbi.nlm.nih.gov/pubmed/17381847
http://dx.doi.org/10.1186/1477-7827-5-13