Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

BACKGROUND: Drug-drug interactions resulting from the inhibition of an enzymatic process can have serious implications for clinical drug therapy. Quantification of the drugs internal exposure increase upon administration with an inhibitor requires understanding to avoid the drug reaching toxic thres...

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Detalles Bibliográficos
Autores principales: Vossen, Michaela, Sevestre, Michael, Niederalt, Christoph, Jang, In-Jin, Willmann, Stefan, Edginton, Andrea N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853074/
https://www.ncbi.nlm.nih.gov/pubmed/17386084
http://dx.doi.org/10.1186/1742-4682-4-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853074/
https://www.ncbi.nlm.nih.gov/pubmed/17386084
http://dx.doi.org/10.1186/1742-4682-4-13

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