Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol

AIM: The effects of 24(S),25-epoxycholesterol (24,25EC) on aspects of cholesterol homeostasis is well-documented. When added to cells, 24,25EC decreases cholesterol synthesis and up-regulates cholesterol efflux genes, including ABCA1. Synthesis of 24,25EC occurs in a shunt of the mevalonate pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Jenny, Quinn, Carmel M, Brown, Andrew J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854894/
https://www.ncbi.nlm.nih.gov/pubmed/17408498
http://dx.doi.org/10.1186/1476-511X-6-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854894/
https://www.ncbi.nlm.nih.gov/pubmed/17408498
http://dx.doi.org/10.1186/1476-511X-6-10

Ejemplares similares