A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding

BACKGROUND: The C-terminal tetratricopeptide (TPR) repeat domain of Pex5p recognises proteins carrying a peroxisomal targeting signal type 1 (PTS1) tripeptide in their C-terminus. Previously, structural data have been obtained from the TPR domain of Pex5p in both the liganded and unliganded states,...

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Detalles Bibliográficos
Autores principales: Stanley, Will A, Pursiainen, Niko V, Garman, Elspeth F, Juffer, André H, Wilmanns, Matthias, Kursula, Petri
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854907/
https://www.ncbi.nlm.nih.gov/pubmed/17428317
http://dx.doi.org/10.1186/1472-6807-7-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854907/
https://www.ncbi.nlm.nih.gov/pubmed/17428317
http://dx.doi.org/10.1186/1472-6807-7-24

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