Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors

Frameshift and nonsense mutations are common in tumors with microsatellite instability, and mRNAs from these mutated genes have premature termination codons (PTCs). Abnormal mRNAs containing PTCs are normally degraded by the nonsense-mediated mRNA decay (NMD) system. However, PTCs located within 50–...

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Detalles Bibliográficos
Autores principales: You, Kwon Tae, Li, Long Shan, Kim, Nam-Gyun, Kang, Hyun Ju, Koh, Kwi Hye, Chwae, Yong-Joon, Kim, Kyoung Mi, Kim, Yoon Ki, Park, Sung Mi, Jang, Sung Key, Kim, Hoguen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854916/
https://www.ncbi.nlm.nih.gov/pubmed/17456004
http://dx.doi.org/10.1371/journal.pbio.0050109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854916/
https://www.ncbi.nlm.nih.gov/pubmed/17456004
http://dx.doi.org/10.1371/journal.pbio.0050109

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