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Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors
Frameshift and nonsense mutations are common in tumors with microsatellite instability, and mRNAs from these mutated genes have premature termination codons (PTCs). Abnormal mRNAs containing PTCs are normally degraded by the nonsense-mediated mRNA decay (NMD) system. However, PTCs located within 50–...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854916/ https://www.ncbi.nlm.nih.gov/pubmed/17456004 http://dx.doi.org/10.1371/journal.pbio.0050109 |