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RNA mutagenesis yields highly diverse mRNA libraries for in vitro protein evolution
BACKGROUND: In protein drug development, in vitro molecular optimization or protein maturation can be used to modify protein properties. One basic approach to protein maturation is the introduction of random DNA mutations into the target gene sequence to produce a library of variants that can be scr...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855321/ https://www.ncbi.nlm.nih.gov/pubmed/17425805 http://dx.doi.org/10.1186/1472-6750-7-18 |