Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice

BACKGROUND: Targeted disruption of the murine 3β-hydroxysterol-Δ7-reductase gene (Dhcr7), an animal model of Smith-Lemli-Opitz syndrome, leads to loss of cholesterol synthesis and neonatal death that can be partially rescued by transgenic replacement of DHCR7 expression in brain during embryogenesis...

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Detalles Bibliográficos
Autores principales: Yu, Hongwei, Li, Man, Tint, G Stephen, Chen, Jianliang, Xu, Guorong, Patel, Shailendra B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855921/
https://www.ncbi.nlm.nih.gov/pubmed/17408495
http://dx.doi.org/10.1186/1471-213X-7-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855921/
https://www.ncbi.nlm.nih.gov/pubmed/17408495
http://dx.doi.org/10.1186/1471-213X-7-27

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