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Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice

BACKGROUND: Targeted disruption of the murine 3β-hydroxysterol-Δ7-reductase gene (Dhcr7), an animal model of Smith-Lemli-Opitz syndrome, leads to loss of cholesterol synthesis and neonatal death that can be partially rescued by transgenic replacement of DHCR7 expression in brain during embryogenesis...

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Detalles Bibliográficos
Autores principales:	Yu, Hongwei, Li, Man, Tint, G Stephen, Chen, Jianliang, Xu, Guorong, Patel, Shailendra B
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855921/ https://www.ncbi.nlm.nih.gov/pubmed/17408495 http://dx.doi.org/10.1186/1471-213X-7-27

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