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The Role of the Octarepeat Region in Neuroprotective Function of the Cellular Prion Protein

Structural alterations of the cellular prion protein (PrP(C)) seem to be the core of the pathogenesis of prion diseases. However, the physiological function of PrP(C )remains an enigma. Cell culture experiments have indicated that PrP(C) and in particular its N‐terminal octarepeat region together wi...

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Detalles Bibliográficos
Autores principales: Mitteregger, Gerda, Vosko, Milan, Krebs, Bjarne, Xiang, Wei, Kohlmannsperger, Veronika, Nölting, Svenja, Hamann, Gerhard F., Kretzschmar, Hans A.
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859984/
https://www.ncbi.nlm.nih.gov/pubmed/17388948
http://dx.doi.org/10.1111/j.1750-3639.2007.00061.x