Cargando…
The Role of the Octarepeat Region in Neuroprotective Function of the Cellular Prion Protein
Structural alterations of the cellular prion protein (PrP(C)) seem to be the core of the pathogenesis of prion diseases. However, the physiological function of PrP(C )remains an enigma. Cell culture experiments have indicated that PrP(C) and in particular its N‐terminal octarepeat region together wi...
Autores principales: | Mitteregger, Gerda, Vosko, Milan, Krebs, Bjarne, Xiang, Wei, Kohlmannsperger, Veronika, Nölting, Svenja, Hamann, Gerhard F., Kretzschmar, Hans A. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859984/ https://www.ncbi.nlm.nih.gov/pubmed/17388948 http://dx.doi.org/10.1111/j.1750-3639.2007.00061.x |
Ejemplares similares
-
Instability of the Octarepeat Region of the Human Prion Protein Gene
por: Li, Baiya, et al.
Publicado: (2011) -
The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)
por: Yam, Alice Y., et al.
Publicado: (2010) -
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
por: Lau, Agnes, et al.
Publicado: (2015) -
The non-octarepeat copper binding site of the prion protein is a key regulator of prion
conversion
por: Giachin, Gabriele, et al.
Publicado: (2015) -
Loss of Octarepeats in Two Processed Prion Pseudogenes in the Red Squirrel, Sciurus vulgaris
por: Madsen, Ole, et al.
Publicado: (2010)