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Protecting exons from deleterious R-loops: a potential advantage of having introns
BACKGROUND: Accumulating evidence indicates that the nascent RNA can invade and pair with one strand of DNA, forming an R-loop structure that threatens the stability of the genome. In addition, the cost and benefit of introns are still in debate. RESULTS: At least three factors are likely required f...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863416/ https://www.ncbi.nlm.nih.gov/pubmed/17459149 http://dx.doi.org/10.1186/1745-6150-2-11 |