Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

BACKGROUND: The retinoblastoma tumor suppressor (Rb) acts in a conserved pathway that is deregulated in most human cancers. Inactivation of the single Rb-related gene in Caenorhabditis elegans, lin-35, has only limited effects on viability and fertility, yet causes changes in cell-fate and cell-cycl...

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Detalles Bibliográficos
Autores principales: Ceron, Julian, Rual, Jean-François, Chandra, Abha, Dupuy, Denis, Vidal, Marc, van den Heuvel, Sander
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863419/
https://www.ncbi.nlm.nih.gov/pubmed/17417969
http://dx.doi.org/10.1186/1471-213X-7-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863419/
https://www.ncbi.nlm.nih.gov/pubmed/17417969
http://dx.doi.org/10.1186/1471-213X-7-30

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