2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity

The synthesis of oligonucleotides containing 2′-deoxy-2′-fluoro-4′-thioarabinonucleotides is described. 2′-Deoxy-2′-fluoro-5-methyl-4′-thioarabinouridine (4′S-FMAU) was incorporated into 18-mer antisense oligonucleotides (AONs). 4′S-FMAU adopts a predominantly northern sugar conformation. Oligonucle...

Descripción completa

Detalles Bibliográficos
Autores principales: Watts, Jonathan K., Choubdar, Niloufar, Sadalapure, Kashinath, Robert, Francis, Wahba, Alexander S., Pelletier, Jerry, Mario Pinto, B., Damha, Masad J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865065/
https://www.ncbi.nlm.nih.gov/pubmed/17284457
http://dx.doi.org/10.1093/nar/gkl1153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865065/
https://www.ncbi.nlm.nih.gov/pubmed/17284457
http://dx.doi.org/10.1093/nar/gkl1153

Ejemplares similares