Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

BACKGROUND: A primary concern when targeting HIV-1 RNA by means of antisense related technologies is the accessibility of the targets. Using a library selection approach to define the most accessible sites for 20-mer oligonucleotides annealing within the highly structured 5'-UTR of the HIV-1 ge...

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Detalles Bibliográficos
Autores principales: Jakobsen, Martin R, Haasnoot, Joost, Wengel, Jesper, Berkhout, Ben, Kjems, Jørgen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866241/
https://www.ncbi.nlm.nih.gov/pubmed/17459171
http://dx.doi.org/10.1186/1742-4690-4-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866241/
https://www.ncbi.nlm.nih.gov/pubmed/17459171
http://dx.doi.org/10.1186/1742-4690-4-29

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