Comparison of type I error for multiple test corrections in large single-nucleotide polymorphism studies using principal components versus haplotype blocking algorithms

Although permutation testing has been the gold standard for assessing significance levels in studies using multiple markers, it is time-consuming. A Bonferroni correction to the nominal p-value that uses the underlying pair-wise linkage disequilibrium (LD) structure among the markers to determine th...

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Detalles Bibliográficos
Autores principales: Nicodemus, Kristin K, Liu, Wenlei, Chase, Gary A, Tsai, Ya-Yu, Fallin, M Daniele
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866703/
https://www.ncbi.nlm.nih.gov/pubmed/16451692
http://dx.doi.org/10.1186/1471-2156-6-S1-S78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866703/
https://www.ncbi.nlm.nih.gov/pubmed/16451692
http://dx.doi.org/10.1186/1471-2156-6-S1-S78

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