Statins Disrupt CCR5 and RANTES Expression Levels in CD4(+) T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1

BACKGROUND: Statins have previously been shown to reduce the in vitro infection of human immunodeficiency virus type 1 (HIV-1) through modulation of Rho GTPase activity and lipid raft formation at the cell surface, as well as by disrupting LFA-1 incorporation into viral particles. PRINCIPLE FINDINGS...

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Detalles Bibliográficos
Autores principales: Nabatov, Alexey A., Pollakis, Georgios, Linnemann, Thomas, Paxton, William A., de Baar, Michel P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867858/
https://www.ncbi.nlm.nih.gov/pubmed/17520029
http://dx.doi.org/10.1371/journal.pone.0000470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867858/
https://www.ncbi.nlm.nih.gov/pubmed/17520029
http://dx.doi.org/10.1371/journal.pone.0000470

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