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Normalization of two-channel microarrays accounting for experimental design and intensity-dependent relationships
In normalizing two-channel expression arrays, the ANOVA approach explicitly incorporates the experimental design in its model, and the MA plot-based approach accounts for intensity-dependent biases. However, both approaches can lead to inaccurate normalization in fairly common scenarios. We propose...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868928/ https://www.ncbi.nlm.nih.gov/pubmed/17391524 http://dx.doi.org/10.1186/gb-2007-8-3-r44 |