The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysis

The genome of the human hepatitis delta virus (HDV) harbors a self-cleaving catalytic RNA motif, the genomic HDV ribozyme, whose crystal structure shows the dangling nucleotides 5′ of the cleavage site projecting away from the catalytic core. This 5′-sequence contains a clinically conserved U − 1 th...

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Detalles Bibliográficos
Autores principales: Sefcikova, Jana, Krasovska, Maryna V., Šponer, Jiří, Walter, Nils G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874588/
https://www.ncbi.nlm.nih.gov/pubmed/17337436
http://dx.doi.org/10.1093/nar/gkl1104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874588/
https://www.ncbi.nlm.nih.gov/pubmed/17337436
http://dx.doi.org/10.1093/nar/gkl1104

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