Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoyl-modified uracils reveal the basis for properties as antigene and antisense molecules

Oligonucleotides containing 5-(N-aminohexyl)carbamoyl-modified uracils have promising features for applications as antigene and antisense therapies. Relative to unmodified DNA, oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2′-deoxyuridine ((N)U) or 5-(N-aminohexyl)carbamoyl-2′-O-methyluridin...

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Detalles Bibliográficos
Autores principales: Juan, Ella Czarina Magat, Kondo, Jiro, Kurihara, Takeshi, Ito, Takanori, Ueno, Yoshihito, Matsuda, Akira, Takénaka, Akio
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874594/
https://www.ncbi.nlm.nih.gov/pubmed/17341465
http://dx.doi.org/10.1093/nar/gkl821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874594/
https://www.ncbi.nlm.nih.gov/pubmed/17341465
http://dx.doi.org/10.1093/nar/gkl821

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