Cancer-derived p53 mutants suppress p53-target gene expression—potential mechanism for gain of function of mutant p53

Tumour-derived p53 mutants are thought to have acquired ‘gain-of-function’ properties that contribute to oncogenicity. We have tested the hypothesis that p53 mutants suppress p53-target gene expression, leading to enhanced cellular growth. Silencing of mutant p53 expression in several human cell lin...

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Detalles Bibliográficos
Autores principales: Vikhanskaya, Faina, Lee, Ming Kei, Mazzoletti, Marco, Broggini, Massimo, Sabapathy, Kanaga
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874625/
https://www.ncbi.nlm.nih.gov/pubmed/17344317
http://dx.doi.org/10.1093/nar/gkm099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874625/
https://www.ncbi.nlm.nih.gov/pubmed/17344317
http://dx.doi.org/10.1093/nar/gkm099

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