Reversible gene knockdown in mice using a tight, inducible shRNA expression system

RNA interference through expression of short hairpin (sh)RNAs provides an efficient approach for gene function analysis in mouse genetics. Techniques allowing to control time and degree of gene silencing in vivo, however, are still lacking. Here we provide a generally applicable system for the tempo...

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Detalles Bibliográficos
Autores principales: Seibler, Jost, Kleinridders, Andre, Küter-Luks, Birgit, Niehaves, Sandra, Brüning, Jens C., Schwenk, Frieder
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874634/
https://www.ncbi.nlm.nih.gov/pubmed/17376804
http://dx.doi.org/10.1093/nar/gkm122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874634/
https://www.ncbi.nlm.nih.gov/pubmed/17376804
http://dx.doi.org/10.1093/nar/gkm122

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