Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes

BACKGROUND: Methylmalonic acidemia (MMA), a common organic aciduria, is caused by deficiency of the mitochondrial localized, 5'deoxyadenosylcobalamin dependent enzyme, methylmalonyl-CoA mutase (MUT). Liver transplantation in the absence of gross hepatic dysfunction provides supportive therapy a...

Descripción completa

Detalles Bibliográficos
Autores principales: Chandler, Randy J, Tsai, Matthew S, Dorko, Kenneth, Sloan, Jennifer, Korson, Mark, Freeman, Richard, Strom, Stephen, Venditti, Charles P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876207/
https://www.ncbi.nlm.nih.gov/pubmed/17470278
http://dx.doi.org/10.1186/1471-2350-8-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876207/
https://www.ncbi.nlm.nih.gov/pubmed/17470278
http://dx.doi.org/10.1186/1471-2350-8-24

Ejemplares similares