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Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons

BACKGROUND: Since the majority of apolipoprotein E (apoE) existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL), one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system. However, the...

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Detalles Bibliográficos
Autores principales: Gong, Jian-Sheng, Morita, Shin-ya, Kobayashi, Mariko, Handa, Tetsurou, Fujita, Shinobu C, Yanagisawa, Katsuhiko, Michikawa, Makoto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876452/
https://www.ncbi.nlm.nih.gov/pubmed/17504523
http://dx.doi.org/10.1186/1750-1326-2-9